Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health
Identifieur interne : 004201 ( Main/Exploration ); précédent : 004200; suivant : 004202Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health
Auteurs : Wim Crielaard [Pays-Bas] ; Egija Zaura [Pays-Bas] ; Annemarie A. Schuller [Pays-Bas] ; Susan M. Huse [États-Unis] ; Roy C. Montijn [Pays-Bas] ; Bart Jf Keijser [Pays-Bas]Source :
- BMC Medical Genomics [ 1755-8794 ] ; 2011.
Abstract
An understanding of the relation of commensal microbiota to health is essential in preventing disease. Here we studied the oral microbial composition of children (N = 74, aged 3 - 18 years) in natural transition from their deciduous to a permanent dentition and related the microbial profiles to their oral health status. The microbial composition of saliva was assessed by barcoded pyrosequencing of the V5-V6 hypervariable regions of the 16 S rRNA, as well as by using phylogenetic microarrays.
Pyrosequencing reads (126174 reads, 1045 unique sequences) represented 8 phyla and 113 higher taxa in saliva samples. Four phyla - Firmicutes, Bacteriodetes, Proteobacteria and Actinobacteria - predominated in all groups. The deciduous dentition harboured a higher proportion of Proteobacteria (Gammaproteobacteria, Moraxellaceae) than Bacteroidetes, while in all other groups Bacteroidetes were at least as abundant as Proteobacteria. Bacteroidetes (mainly genus
Microarray analysis enabled further analysis of the individual salivary microbiota. Of 350 microarray probes, 156 gave a positive signal with, on average, 77 (range 48-93) probes per individual sample.
A caries-free oral status significantly associated with the higher signal of the probes targeting
The potential role of
Url:
DOI: 10.1186/1755-8794-4-22
PubMed: 21371338
PubMed Central: 3058002
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002849
- to stream Pmc, to step Curation: 002849
- to stream Pmc, to step Checkpoint: 002179
- to stream Ncbi, to step Merge: 003497
- to stream Ncbi, to step Curation: 003497
- to stream Ncbi, to step Checkpoint: 003497
- to stream Main, to step Merge: 004227
- to stream Main, to step Curation: 004201
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health</title><author><name sortKey="Crielaard, Wim" sort="Crielaard, Wim" uniqKey="Crielaard W" first="Wim" last="Crielaard">Wim Crielaard</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam</wicri:regionArea><wicri:noRegion>1081 LA Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam</wicri:regionArea><wicri:noRegion>1081 LA Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Schuller, Annemarie A" sort="Schuller, Annemarie A" uniqKey="Schuller A" first="Annemarie A" last="Schuller">Annemarie A. Schuller</name><affiliation wicri:level="1"><nlm:aff id="I2">TNO Quality of Life, PO box 2215, 2301 CE Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>TNO Quality of Life, PO box 2215, 2301 CE Leiden</wicri:regionArea><wicri:noRegion>2301 CE Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Huse, Susan M" sort="Huse, Susan M" uniqKey="Huse S" first="Susan M" last="Huse">Susan M. Huse</name><affiliation wicri:level="2"><nlm:aff id="I3">Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Montijn, Roy C" sort="Montijn, Roy C" uniqKey="Montijn R" first="Roy C" last="Montijn">Roy C. Montijn</name><affiliation wicri:level="1"><nlm:aff id="I4">TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist</wicri:regionArea><wicri:noRegion>3704 HE Zeist</wicri:noRegion></affiliation></author><author><name sortKey="Keijser, Bart Jf" sort="Keijser, Bart Jf" uniqKey="Keijser B" first="Bart Jf" last="Keijser">Bart Jf Keijser</name><affiliation wicri:level="1"><nlm:aff id="I4">TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist</wicri:regionArea><wicri:noRegion>3704 HE Zeist</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21371338</idno><idno type="pmc">3058002</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058002</idno><idno type="RBID">PMC:3058002</idno><idno type="doi">10.1186/1755-8794-4-22</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002849</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002849</idno><idno type="wicri:Area/Pmc/Curation">002849</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002849</idno><idno type="wicri:Area/Pmc/Checkpoint">002179</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002179</idno><idno type="wicri:Area/Ncbi/Merge">003497</idno><idno type="wicri:Area/Ncbi/Curation">003497</idno><idno type="wicri:Area/Ncbi/Checkpoint">003497</idno><idno type="wicri:Area/Main/Merge">004227</idno><idno type="wicri:Area/Main/Curation">004201</idno><idno type="wicri:Area/Main/Exploration">004201</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health</title><author><name sortKey="Crielaard, Wim" sort="Crielaard, Wim" uniqKey="Crielaard W" first="Wim" last="Crielaard">Wim Crielaard</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam</wicri:regionArea><wicri:noRegion>1081 LA Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Experimental Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam</wicri:regionArea><wicri:noRegion>1081 LA Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Schuller, Annemarie A" sort="Schuller, Annemarie A" uniqKey="Schuller A" first="Annemarie A" last="Schuller">Annemarie A. Schuller</name><affiliation wicri:level="1"><nlm:aff id="I2">TNO Quality of Life, PO box 2215, 2301 CE Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>TNO Quality of Life, PO box 2215, 2301 CE Leiden</wicri:regionArea><wicri:noRegion>2301 CE Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Huse, Susan M" sort="Huse, Susan M" uniqKey="Huse S" first="Susan M" last="Huse">Susan M. Huse</name><affiliation wicri:level="2"><nlm:aff id="I3">Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Montijn, Roy C" sort="Montijn, Roy C" uniqKey="Montijn R" first="Roy C" last="Montijn">Roy C. Montijn</name><affiliation wicri:level="1"><nlm:aff id="I4">TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist</wicri:regionArea><wicri:noRegion>3704 HE Zeist</wicri:noRegion></affiliation></author><author><name sortKey="Keijser, Bart Jf" sort="Keijser, Bart Jf" uniqKey="Keijser B" first="Bart Jf" last="Keijser">Bart Jf Keijser</name><affiliation wicri:level="1"><nlm:aff id="I4">TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Utrechtseweg 48, 3704 HE Zeist</wicri:regionArea><wicri:noRegion>3704 HE Zeist</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Medical Genomics</title><idno type="eISSN">1755-8794</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>An understanding of the relation of commensal microbiota to health is essential in preventing disease. Here we studied the oral microbial composition of children (N = 74, aged 3 - 18 years) in natural transition from their deciduous to a permanent dentition and related the microbial profiles to their oral health status. The microbial composition of saliva was assessed by barcoded pyrosequencing of the V5-V6 hypervariable regions of the 16 S rRNA, as well as by using phylogenetic microarrays.</p></sec><sec><title>Results</title><p>Pyrosequencing reads (126174 reads, 1045 unique sequences) represented 8 phyla and 113 higher taxa in saliva samples. Four phyla - Firmicutes, Bacteriodetes, Proteobacteria and Actinobacteria - predominated in all groups. The deciduous dentition harboured a higher proportion of Proteobacteria (Gammaproteobacteria, Moraxellaceae) than Bacteroidetes, while in all other groups Bacteroidetes were at least as abundant as Proteobacteria. Bacteroidetes (mainly genus <italic>Prevotella</italic>), Veillonellaceae family, Spirochaetes and candidate division TM7 increased with increasing age, reflecting maturation of the microbiome driven by biological changes with age.</p><p>Microarray analysis enabled further analysis of the individual salivary microbiota. Of 350 microarray probes, 156 gave a positive signal with, on average, 77 (range 48-93) probes per individual sample.</p><p>A caries-free oral status significantly associated with the higher signal of the probes targeting <italic>Porphyromonas catoniae </italic>and <italic>Neisseria flavescens</italic>.</p></sec><sec><title>Conclusions</title><p>The potential role of <italic>P. catoniae </italic>and <italic>N. flavescens </italic>as oral health markers should be assessed in large-scale clinical studies. The combination of both, open-ended and targeted molecular approaches provides us with information that will increase our understanding of the interplay between the human host and its microbiome.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Keijser, Bjf" uniqKey="Keijser B">BJF Keijser</name></author><author><name sortKey="Zaura, E" uniqKey="Zaura E">E Zaura</name></author><author><name sortKey="Huse, Sm" uniqKey="Huse S">SM Huse</name></author><author><name sortKey="Van Der Vossen, Jmbm" uniqKey="Van Der Vossen J">JMBM van der Vossen</name></author><author><name sortKey="Schuren, Fhj" uniqKey="Schuren F">FHJ Schuren</name></author><author><name sortKey="Montijn, Rc" uniqKey="Montijn R">RC Montijn</name></author><author><name sortKey="Ten Cate, Jm" uniqKey="Ten Cate J">JM ten Cate</name></author><author><name sortKey="Crielaard, W" uniqKey="Crielaard W">W Crielaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paster, Bj" uniqKey="Paster B">BJ Paster</name></author><author><name sortKey="Olsen, I" uniqKey="Olsen I">I Olsen</name></author><author><name sortKey="Aas, Ja" uniqKey="Aas J">JA Aas</name></author><author><name sortKey="Dewhirst, Fe" uniqKey="Dewhirst F">FE Dewhirst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aas, Ja" uniqKey="Aas J">JA Aas</name></author><author><name sortKey="Paster, Bj" uniqKey="Paster B">BJ Paster</name></author><author><name sortKey="Stokes, Ln" uniqKey="Stokes L">LN Stokes</name></author><author><name sortKey="Olsen, I" uniqKey="Olsen I">I Olsen</name></author><author><name sortKey="Dewhirst, Fe" uniqKey="Dewhirst F">FE Dewhirst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaura, E" uniqKey="Zaura E">E Zaura</name></author><author><name sortKey="Keijser, Bjf" uniqKey="Keijser B">BJF Keijser</name></author><author><name sortKey="Huse, Sm" uniqKey="Huse S">SM Huse</name></author><author><name sortKey="Crielaard, W" uniqKey="Crielaard W">W Crielaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costello, Ek" uniqKey="Costello E">EK Costello</name></author><author><name sortKey="Lauber, Cl" uniqKey="Lauber C">CL Lauber</name></author><author><name sortKey="Hamady, M" uniqKey="Hamady M">M Hamady</name></author><author><name sortKey="Fierer, N" uniqKey="Fierer N">N Fierer</name></author><author><name sortKey="Gordon, Ji" uniqKey="Gordon J">JI Gordon</name></author><author><name sortKey="Knight, R" uniqKey="Knight R">R Knight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kononen, E" uniqKey="Kononen E">E Könönen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kononen, E" uniqKey="Kononen E">E Kononen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tusher, Vg" uniqKey="Tusher V">VG Tusher</name></author><author><name sortKey="Tibshirani, R" uniqKey="Tibshirani R">R Tibshirani</name></author><author><name sortKey="Chu, G" uniqKey="Chu G">G Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quince, C" uniqKey="Quince C">C Quince</name></author><author><name sortKey="Lanzen, A" uniqKey="Lanzen A">A Lanzen</name></author><author><name sortKey="Curtis, Tp" uniqKey="Curtis T">TP Curtis</name></author><author><name sortKey="Davenport, Rj" uniqKey="Davenport R">RJ Davenport</name></author><author><name sortKey="Hall, N" uniqKey="Hall N">N Hall</name></author><author><name sortKey="Head, Im" uniqKey="Head I">IM Head</name></author><author><name sortKey="Read, Lf" uniqKey="Read L">LF Read</name></author><author><name sortKey="Sloan, Wt" uniqKey="Sloan W">WT Sloan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kunin, V" uniqKey="Kunin V">V Kunin</name></author><author><name sortKey="Engelbrektson, A" uniqKey="Engelbrektson A">A Engelbrektson</name></author><author><name sortKey="Ochman, H" uniqKey="Ochman H">H Ochman</name></author><author><name sortKey="Hugenholtz, P" uniqKey="Hugenholtz P">P Hugenholtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuanazzi, D" uniqKey="Zuanazzi D">D Zuanazzi</name></author><author><name sortKey="Souto, R" uniqKey="Souto R">R Souto</name></author><author><name sortKey="Mattos, Mba" uniqKey="Mattos M">MBA Mattos</name></author><author><name sortKey="Zuanazzi, Mr" uniqKey="Zuanazzi M">MR Zuanazzi</name></author><author><name sortKey="Tura, Br" uniqKey="Tura B">BR Tura</name></author><author><name sortKey="Sansone, C" uniqKey="Sansone C">C Sansone</name></author><author><name sortKey="Colombo, Apv" uniqKey="Colombo A">APV Colombo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fourrier, Fmd" uniqKey="Fourrier F">FMD Fourrier</name></author><author><name sortKey="Duvivier, Bdmd" uniqKey="Duvivier B">BDMD Duvivier</name></author><author><name sortKey="Boutigny, Hdmd" uniqKey="Boutigny H">HDMD Boutigny</name></author><author><name sortKey="Roussel Delvallez, Mmd" uniqKey="Roussel Delvallez M">MMD Roussel-Delvallez</name></author><author><name sortKey="Chopin, Cmd" uniqKey="Chopin C">CMD Chopin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livermore, Dm" uniqKey="Livermore D">DM Livermore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peleg, Ay" uniqKey="Peleg A">AY Peleg</name></author><author><name sortKey="Seifert, H" uniqKey="Seifert H">H Seifert</name></author><author><name sortKey="Paterson, Dl" uniqKey="Paterson D">DL Paterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Staaij, Bk" uniqKey="Van Staaij B">BK Van Staaij</name></author><author><name sortKey="Akker, Ehvd" uniqKey="Akker E">EHVD Akker</name></author><author><name sortKey="Van Dorsser, Ehmdh" uniqKey="Van Dorsser E">EHMDH Van Dorsser</name></author><author><name sortKey="Fleer, A" uniqKey="Fleer A">A Fleer</name></author><author><name sortKey="Hoes, Aw" uniqKey="Hoes A">AW Hoes</name></author><author><name sortKey="Schilder, Agm" uniqKey="Schilder A">AGM Schilder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsson, L" uniqKey="Matsson L">L Matsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papaioannou, W" uniqKey="Papaioannou W">W Papaioannou</name></author><author><name sortKey="Gizani, S" uniqKey="Gizani S">S Gizani</name></author><author><name sortKey="Haffajee, Ad" uniqKey="Haffajee A">AD Haffajee</name></author><author><name sortKey="Quirynen, M" uniqKey="Quirynen M">M Quirynen</name></author><author><name sortKey="Mamai Homata, E" uniqKey="Mamai Homata E">E Mamai-Homata</name></author><author><name sortKey="Papagiannoulis, L" uniqKey="Papagiannoulis L">L Papagiannoulis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsson, L" uniqKey="Matsson L">L Matsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bimstein, E" uniqKey="Bimstein E">E Bimstein</name></author><author><name sortKey="Matsson, L" uniqKey="Matsson L">L Matsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimura, S" uniqKey="Kimura S">S Kimura</name></author><author><name sortKey="Ooshima, T" uniqKey="Ooshima T">T Ooshima</name></author><author><name sortKey="Takiguchi, M" uniqKey="Takiguchi M">M Takiguchi</name></author><author><name sortKey="Sasaki, Y" uniqKey="Sasaki Y">Y Sasaki</name></author><author><name sortKey="Amano, A" uniqKey="Amano A">A Amano</name></author><author><name sortKey="Morisaki, I" uniqKey="Morisaki I">I Morisaki</name></author><author><name sortKey="Hamada, S" uniqKey="Hamada S">S Hamada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Lillo, A" uniqKey="De Lillo A">A de Lillo</name></author><author><name sortKey="Booth, V" uniqKey="Booth V">V Booth</name></author><author><name sortKey="Kyriacou, L" uniqKey="Kyriacou L">L Kyriacou</name></author><author><name sortKey="Weightman, Aj" uniqKey="Weightman A">AJ Weightman</name></author><author><name sortKey="Wade, Wg" uniqKey="Wade W">WG Wade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Socransky, Ss" uniqKey="Socransky S">SS Socransky</name></author><author><name sortKey="Haffajee, Ad" uniqKey="Haffajee A">AD Haffajee</name></author><author><name sortKey="Cugini, Ma" uniqKey="Cugini M">MA Cugini</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author><author><name sortKey="Kent, Rl" uniqKey="Kent R">RL Kent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kononen, E" uniqKey="Kononen E">E Könönen</name></author><author><name sortKey="Asikainen, S" uniqKey="Asikainen S">S Asikainen</name></author><author><name sortKey="Saarela, M" uniqKey="Saarela M">M Saarela</name></author><author><name sortKey="Karjalainen, J" uniqKey="Karjalainen J">J Karjalainen</name></author><author><name sortKey="Jousimies Somer, H" uniqKey="Jousimies Somer H">H Jousimies-Somer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willems, A" uniqKey="Willems A">A Willems</name></author><author><name sortKey="Collins, M" uniqKey="Collins M">M Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Lvh" uniqKey="Moore L">LVH Moore</name></author><author><name sortKey="Moore, Wec" uniqKey="Moore W">WEC Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kononen, E" uniqKey="Kononen E">E Kononen</name></author><author><name sortKey="Kanervo, A" uniqKey="Kanervo A">A Kanervo</name></author><author><name sortKey="Takala, A" uniqKey="Takala A">A Takala</name></author><author><name sortKey="Asikainen, S" uniqKey="Asikainen S">S Asikainen</name></author><author><name sortKey="Jousimies Somer, H" uniqKey="Jousimies Somer H">H Jousimies-Somer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kononen, E" uniqKey="Kononen E">E Könönen</name></author><author><name sortKey="V Is Nen, Ml" uniqKey="V Is Nen M">ML Väisänen</name></author><author><name sortKey="Finegold, Sm" uniqKey="Finegold S">SM Finegold</name></author><author><name sortKey="Heine, R" uniqKey="Heine R">R Heine</name></author><author><name sortKey="Jousimies Somer, H" uniqKey="Jousimies Somer H">H Jousimies-Somer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nyfors, S" uniqKey="Nyfors S">S Nyfors</name></author><author><name sortKey="Kononen, E" uniqKey="Kononen E">E Kononen</name></author><author><name sortKey="Takala, A" uniqKey="Takala A">A Takala</name></author><author><name sortKey="Jousimies Somer, H" uniqKey="Jousimies Somer H">H Jousimies-Somer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Winkelhoff, Aj" uniqKey="Van Winkelhoff A">AJ van Winkelhoff</name></author><author><name sortKey="Rijnsburger, Mc" uniqKey="Rijnsburger M">MC Rijnsburger</name></author><author><name sortKey="Van Der Velden, U" uniqKey="Van Der Velden U">U van der Velden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohler, B" uniqKey="Kohler B">B Köhler</name></author><author><name sortKey="Lundberg, A B" uniqKey="Lundberg A">A-B Lundberg</name></author><author><name sortKey="Birkhed, D" uniqKey="Birkhed D">D Birkhed</name></author><author><name sortKey="Papapanou, Pn" uniqKey="Papapanou P">PN Papapanou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Domejean, S" uniqKey="Domejean S">S Domejean</name></author><author><name sortKey="Zhan, L" uniqKey="Zhan L">L Zhan</name></author><author><name sortKey="Denbesten, Pk" uniqKey="Denbesten P">PK DenBesten</name></author><author><name sortKey="Stamper, J" uniqKey="Stamper J">J Stamper</name></author><author><name sortKey="Boyce, Wt" uniqKey="Boyce W">WT Boyce</name></author><author><name sortKey="Featherstone, Jd" uniqKey="Featherstone J">JD Featherstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, We" uniqKey="Moore W">WE Moore</name></author><author><name sortKey="Burmeister, Ja" uniqKey="Burmeister J">JA Burmeister</name></author><author><name sortKey="Brooks, Cn" uniqKey="Brooks C">CN Brooks</name></author><author><name sortKey="Ranney, Rr" uniqKey="Ranney R">RR Ranney</name></author><author><name sortKey="Hinkelmann, Kh" uniqKey="Hinkelmann K">KH Hinkelmann</name></author><author><name sortKey="Schieken, Rm" uniqKey="Schieken R">RM Schieken</name></author><author><name sortKey="Moore, Lv" uniqKey="Moore L">LV Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corby, Pm" uniqKey="Corby P">PM Corby</name></author><author><name sortKey="Bretz, Wa" uniqKey="Bretz W">WA Bretz</name></author><author><name sortKey="Hart, Tc" uniqKey="Hart T">TC Hart</name></author><author><name sortKey="Schork, Nj" uniqKey="Schork N">NJ Schork</name></author><author><name sortKey="Wessel, J" uniqKey="Wessel J">J Wessel</name></author><author><name sortKey="Lyons Weiler, J" uniqKey="Lyons Weiler J">J Lyons-Weiler</name></author><author><name sortKey="Paster, Bj" uniqKey="Paster B">BJ Paster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greene, Jc" uniqKey="Greene J">JC Greene</name></author><author><name sortKey="Vermillion, Jr" uniqKey="Vermillion J">JR Vermillion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sogin, Ml" uniqKey="Sogin M">ML Sogin</name></author><author><name sortKey="Morrison, Hg" uniqKey="Morrison H">HG Morrison</name></author><author><name sortKey="Huber, Ja" uniqKey="Huber J">JA Huber</name></author><author><name sortKey="Mark Welch, D" uniqKey="Mark Welch D">D Mark Welch</name></author><author><name sortKey="Huse, Sm" uniqKey="Huse S">SM Huse</name></author><author><name sortKey="Neal, Pr" uniqKey="Neal P">PR Neal</name></author><author><name sortKey="Arrieta, Jm" uniqKey="Arrieta J">JM Arrieta</name></author><author><name sortKey="Herndl, Gj" uniqKey="Herndl G">GJ Herndl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huse, Sm" uniqKey="Huse S">SM Huse</name></author><author><name sortKey="Dethlefsen, L" uniqKey="Dethlefsen L">L Dethlefsen</name></author><author><name sortKey="Huber, Ja" uniqKey="Huber J">JA Huber</name></author><author><name sortKey="Mark Welch, D" uniqKey="Mark Welch D">D Mark Welch</name></author><author><name sortKey="Relman, Da" uniqKey="Relman D">DA Relman</name></author><author><name sortKey="Sogin, Ml" uniqKey="Sogin M">ML Sogin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pruesse, E" uniqKey="Pruesse E">E Pruesse</name></author><author><name sortKey="Quast, C" uniqKey="Quast C">C Quast</name></author><author><name sortKey="Knittel, K" uniqKey="Knittel K">K Knittel</name></author><author><name sortKey="Fuchs, Bm" uniqKey="Fuchs B">BM Fuchs</name></author><author><name sortKey="Ludwig, W" uniqKey="Ludwig W">W Ludwig</name></author><author><name sortKey="Peplies, J" uniqKey="Peplies J">J Peplies</name></author><author><name sortKey="Glockner, Fo" uniqKey="Glockner F">FO Glockner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cole, Jr" uniqKey="Cole J">JR Cole</name></author><author><name sortKey="Chai, B" uniqKey="Chai B">B Chai</name></author><author><name sortKey="Farris, Rj" uniqKey="Farris R">RJ Farris</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Kulam, Sa" uniqKey="Kulam S">SA Kulam</name></author><author><name sortKey="Mcgarrell, Dm" uniqKey="Mcgarrell D">DM McGarrell</name></author><author><name sortKey="Garrity, Gm" uniqKey="Garrity G">GM Garrity</name></author><author><name sortKey="Tiedje, Jm" uniqKey="Tiedje J">JM Tiedje</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paster, Bj" uniqKey="Paster B">BJ Paster</name></author><author><name sortKey="Boches, Sk" uniqKey="Boches S">SK Boches</name></author><author><name sortKey="Galvin, Jl" uniqKey="Galvin J">JL Galvin</name></author><author><name sortKey="Ericson, Re" uniqKey="Ericson R">RE Ericson</name></author><author><name sortKey="Lau, Cn" uniqKey="Lau C">CN Lau</name></author><author><name sortKey="Levanos, Va" uniqKey="Levanos V">VA Levanos</name></author><author><name sortKey="Sahasrabudhe, A" uniqKey="Sahasrabudhe A">A Sahasrabudhe</name></author><author><name sortKey="Dewhirst, Fe" uniqKey="Dewhirst F">FE Dewhirst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aas, Ja" uniqKey="Aas J">JA Aas</name></author><author><name sortKey="Griffen, Al" uniqKey="Griffen A">AL Griffen</name></author><author><name sortKey="Dardis, Sr" uniqKey="Dardis S">SR Dardis</name></author><author><name sortKey="Lee, Am" uniqKey="Lee A">AM Lee</name></author><author><name sortKey="Olsen, I" uniqKey="Olsen I">I Olsen</name></author><author><name sortKey="Dewhirst, Fe" uniqKey="Dewhirst F">FE Dewhirst</name></author><author><name sortKey="Leys, Ej" uniqKey="Leys E">EJ Leys</name></author><author><name sortKey="Paster, Bj" uniqKey="Paster B">BJ Paster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakamoto, M" uniqKey="Sakamoto M">M Sakamoto</name></author><author><name sortKey="Rocas, In" uniqKey="Rocas I">IN Rocas</name></author><author><name sortKey="Siqueira, Jf" uniqKey="Siqueira J">JF Siqueira</name></author><author><name sortKey="Benno, Y" uniqKey="Benno Y">Y Benno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludwig, W" uniqKey="Ludwig W">W Ludwig</name></author><author><name sortKey="Strunk, O" uniqKey="Strunk O">O Strunk</name></author><author><name sortKey="Westram, R" uniqKey="Westram R">R Westram</name></author><author><name sortKey="Richter, L" uniqKey="Richter L">L Richter</name></author><author><name sortKey="Meier, H" uniqKey="Meier H">H Meier</name></author><author><name sortKey="Buchner, A" uniqKey="Buchner A">A Buchner</name></author><author><name sortKey="Lai, T" uniqKey="Lai T">T Lai</name></author><author><name sortKey="Steppi, S" uniqKey="Steppi S">S Steppi</name></author><author><name sortKey="Jobb, G" uniqKey="Jobb G">G Jobb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nadkarni, Ma" uniqKey="Nadkarni M">MA Nadkarni</name></author><author><name sortKey="Martin, Fe" uniqKey="Martin F">FE Martin</name></author><author><name sortKey="Jacques, Na" uniqKey="Jacques N">NA Jacques</name></author><author><name sortKey="Hunter, N" uniqKey="Hunter N">N Hunter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saeed, Ai" uniqKey="Saeed A">AI Saeed</name></author><author><name sortKey="Bhagabati, Nk" uniqKey="Bhagabati N">NK Bhagabati</name></author><author><name sortKey="Braisted, Jc" uniqKey="Braisted J">JC Braisted</name></author><author><name sortKey="Liang, W" uniqKey="Liang W">W Liang</name></author><author><name sortKey="Sharov, V" uniqKey="Sharov V">V Sharov</name></author><author><name sortKey="Howe, Ea" uniqKey="Howe E">EA Howe</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Thiagarajan, M" uniqKey="Thiagarajan M">M Thiagarajan</name></author><author><name sortKey="White, Ja" uniqKey="White J">JA White</name></author><author><name sortKey="Quackenbush, J" uniqKey="Quackenbush J">J Quackenbush</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Crielaard, Wim" sort="Crielaard, Wim" uniqKey="Crielaard W" first="Wim" last="Crielaard">Wim Crielaard</name></noRegion><name sortKey="Keijser, Bart Jf" sort="Keijser, Bart Jf" uniqKey="Keijser B" first="Bart Jf" last="Keijser">Bart Jf Keijser</name><name sortKey="Montijn, Roy C" sort="Montijn, Roy C" uniqKey="Montijn R" first="Roy C" last="Montijn">Roy C. Montijn</name><name sortKey="Schuller, Annemarie A" sort="Schuller, Annemarie A" uniqKey="Schuller A" first="Annemarie A" last="Schuller">Annemarie A. Schuller</name><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Huse, Susan M" sort="Huse, Susan M" uniqKey="Huse S" first="Susan M" last="Huse">Susan M. Huse</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004201 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004201 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3058002
|texte= Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21371338" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |